Project 4

Mechanisms of chemotherapy-induced neuropathic pain

We are presently studying the cellular and molecular alterations associated to acute and subchronic treatment using various antitumoral agents. These compounds produce generalized neuropathic pain states which are poorly understood.

Recent Publications

Charlet A, Lasbennes F, Darbon P, Poisbeau (2008) Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms. Pain 139(3):603 - 609.

Luis-Delgado OE, Barrot M, Rodeau JL, Ulery PG, Freund-Mercier MJ, Lasbennes F (2006) The transcription factor DeltaFosB is recruited by inflammatory pain. J Neurochem. 98(5):1423-31.

Luis-Delgado OE, Barrot M, Rodeau JL, Schott G, Benbouzid M, Poisbeau P, Freund-Mercier MJ, Lasbennes F (2006) Calibrated forceps: a sensitive and reliable tool for pain and analgesia studies.J Pain. 7(1):32-9.

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